Primary Sjögren's syndrome is associated with significant cognitive dysfunction
Identifieur interne : 000D93 ( Main/Exploration ); précédent : 000D92; suivant : 000D94Primary Sjögren's syndrome is associated with significant cognitive dysfunction
Auteurs : Mehmet Engin Tezcan [Turquie] ; Emine Belgin Kocer [Turquie] ; Seminur Haznedaroglu [Turquie] ; Cemile Sonmez [Turquie] ; Ridvan Mercan [Turquie] ; Aysegul Atak Yucel [Turquie] ; Ceyla Irkec [Turquie] ; Berivan Bitik [Turquie] ; Berna Goker [Turquie]Source :
- International Journal of Rheumatic Diseases [ 1756-1841 ] ; 2016-10.
Abstract
Aim: Cognitive dysfunction is a neurologic manifestation in primary Sjögren syndrome (PSS). On the other hand, several antibodies are related to cognitive dysfunction. The aim of this study is to assess the cognitive dysfunction of PSS patients via detailed neurologic tests. Moreover, its associations with antibodies were also evaluated. Method: Twenty‐eight female patients with PSS and 17 healthy controls comprised the study groups. Short‐term memory, long‐term memory, verbal learning, visual memory, visual spatial perception, attention, verbal frequency function, executive functions and information processing speed were evaluated with neurologic tests in both of the study groups. Furthermore, anti‐N‐methyl‐D‐aspartate (NMDA) type anti‐glutamate‐receptor antibody, anti‐ribosomal‐p and antiganglioside antibodies were assessed in the study groups. Results: The attention, data processing speed, verbal learning, short‐term verbal memory and visuo‐spatial perception performances were lower in the patients with PSS when compared to the healthy controls. The difference reached statistical significance in Paced Auditory Serial Addition Test (P < 0.01), Serial Digit Learning Test (P < 0.01), clock drawing (P = 0.03), Auditory Verbal Learning Test immediate verbal memory (P = 0.01) and Benton Judgement of Line Orientation Test (P = 0.03). Even if antiganglioside antibodies were more likely to be present in the PSS group when compared to the healthy controls, no relationship was found between its positivity and cognitive dysfunction. Conclusion: Results of this study suggest that cognitive dysfunction is quite prevalent in PSS patients without being associated with studied antibodies.
Url:
DOI: 10.1111/1756-185X.12912
Affiliations:
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dysfunction is a neurologic manifestation in primary Sjögren syndrome (PSS). On the other hand, several antibodies are related to cognitive dysfunction. The aim of this study is to assess the cognitive dysfunction of PSS patients via detailed neurologic tests. Moreover, its associations with antibodies were also evaluated. Method: Twenty‐eight female patients with PSS and 17 healthy controls comprised the study groups. Short‐term memory, long‐term memory, verbal learning, visual memory, visual spatial perception, attention, verbal frequency function, executive functions and information processing speed were evaluated with neurologic tests in both of the study groups. Furthermore, anti‐N‐methyl‐D‐aspartate (NMDA) type anti‐glutamate‐receptor antibody, anti‐ribosomal‐p and antiganglioside antibodies were assessed in the study groups. Results: The attention, data processing speed, verbal learning, short‐term verbal memory and visuo‐spatial perception performances were lower in the patients with PSS when compared to the healthy controls. The difference reached statistical significance in Paced Auditory Serial Addition Test (P < 0.01), Serial Digit Learning Test (P < 0.01), clock drawing (P = 0.03), Auditory Verbal Learning Test immediate verbal memory (P = 0.01) and Benton Judgement of Line Orientation Test (P = 0.03). Even if antiganglioside antibodies were more likely to be present in the PSS group when compared to the healthy controls, no relationship was found between its positivity and cognitive dysfunction. Conclusion: Results of this study suggest that cognitive dysfunction is quite prevalent in PSS patients without being associated with studied antibodies.</div></front></TEI><affiliations><list><country><li>Turquie</li></country></list><tree><country name="Turquie"><noRegion><name sortKey="Tezcan, Mehmet Engin" sort="Tezcan, Mehmet Engin" uniqKey="Tezcan M" first="Mehmet Engin" last="Tezcan">Mehmet Engin Tezcan</name></noRegion><name sortKey="Bitik, Berivan" sort="Bitik, Berivan" uniqKey="Bitik B" first="Berivan" last="Bitik">Berivan Bitik</name><name sortKey="Goker, Berna" sort="Goker, Berna" uniqKey="Goker B" first="Berna" last="Goker">Berna Goker</name><name sortKey="Haznedaroglu, Seminur" sort="Haznedaroglu, Seminur" uniqKey="Haznedaroglu S" first="Seminur" last="Haznedaroglu">Seminur Haznedaroglu</name><name sortKey="Irkec, Ceyla" sort="Irkec, Ceyla" uniqKey="Irkec C" first="Ceyla" last="Irkec">Ceyla Irkec</name><name sortKey="Kocer, Emine Belgin" sort="Kocer, Emine Belgin" uniqKey="Kocer E" first="Emine Belgin" last="Kocer">Emine Belgin Kocer</name><name sortKey="Mercan, Ridvan" sort="Mercan, Ridvan" uniqKey="Mercan R" first="Ridvan" last="Mercan">Ridvan Mercan</name><name sortKey="Sonmez, Cemile" sort="Sonmez, Cemile" uniqKey="Sonmez C" first="Cemile" last="Sonmez">Cemile Sonmez</name><name sortKey="Yucel, Aysegul Atak" sort="Yucel, Aysegul Atak" uniqKey="Yucel A" first="Aysegul Atak" last="Yucel">Aysegul Atak Yucel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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